Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology
Identifieur interne : 001406 ( Main/Exploration ); précédent : 001405; suivant : 001407Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology
Auteurs : D. Lemaire ; T. Barbosa ; P. Rihet [France]Source :
- Brazilian Journal of Medical and Biological Research [ 0100-879X ] ; 2011.
Abstract
Vaccine development faces major difficulties partly because of genetic variation in both infectious organisms and humans. This causes antigenic variation in infectious agents and a high interindividual variability in the human response to the vaccine. The exponential growth of genome sequence information has induced a shift from conventional culture-based to genome-based vaccinology, and allows the tackling of challenges in vaccine development due to pathogen genetic variability. Additionally, recent advances in immunogenetics and genomics should help in the understanding of the influence of genetic factors on the interindividual and interpopulation variations in immune responses to vaccines, and could be useful for developing new vaccine strategies. Accumulating results provide evidence for the existence of a number of genes involved in protective immune responses that are induced either by natural infections or vaccines. Variation in immune responses could be viewed as the result of a perturbation of gene networks; this should help in understanding how a particular polymorphism or a combination thereof could affect protective immune responses. Here we will present: i) the first genome-based vaccines that served as proof of concept, and that provided new critical insights into vaccine development strategies; ii) an overview of genetic predisposition in infectious diseases and genetic control in responses to vaccines; iii) population genetic differences that are a rationale behind group-targeted vaccines; iv) an outlook for genetic control in infectious diseases, with special emphasis on the concept of molecular networks that will provide a structure to the huge amount of genomic data.
Url:
DOI: 10.1590/S0100-879X2011007500142
PubMed: 22030866
PubMed Central: 3854287
Affiliations:
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Lemaire</name><affiliation><nlm:aff id="aff1">Universidade Federal da Bahia and Universidade Estadual da Bahia, Salvador, BA Brasil,</nlm:aff><wicri:noCountry code="subfield">BA Brasil</wicri:noCountry></affiliation></author><author><name sortKey="Barbosa, T" sort="Barbosa, T" uniqKey="Barbosa T" first="T." last="Barbosa">T. Barbosa</name><affiliation><nlm:aff id="aff2">Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA Brasil,</nlm:aff><wicri:noCountry code="subfield">BA Brasil</wicri:noCountry></affiliation></author><author><name sortKey="Rihet, P" sort="Rihet, P" uniqKey="Rihet P" first="P." last="Rihet">P. Rihet</name><affiliation wicri:level="4"><nlm:aff id="aff3">TAGC-INSERM U928, Aix-Marseille Université, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>TAGC-INSERM U928, Aix-Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author></analytic><series><title level="j">Brazilian Journal of Medical and Biological Research</title><idno type="ISSN">0100-879X</idno><idno type="eISSN">1414-431X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="para1">Vaccine development faces major difficulties partly because of genetic variation in both infectious organisms and humans. This causes antigenic variation in infectious agents and a high interindividual variability in the human response to the vaccine. The exponential growth of genome sequence information has induced a shift from conventional culture-based to genome-based vaccinology, and allows the tackling of challenges in vaccine development due to pathogen genetic variability. Additionally, recent advances in immunogenetics and genomics should help in the understanding of the influence of genetic factors on the interindividual and interpopulation variations in immune responses to vaccines, and could be useful for developing new vaccine strategies. Accumulating results provide evidence for the existence of a number of genes involved in protective immune responses that are induced either by natural infections or vaccines. Variation in immune responses could be viewed as the result of a perturbation of gene networks; this should help in understanding how a particular polymorphism or a combination thereof could affect protective immune responses. Here we will present: i) the first genome-based vaccines that served as proof of concept, and that provided new critical insights into vaccine development strategies; ii) an overview of genetic predisposition in infectious diseases and genetic control in responses to vaccines; iii) population genetic differences that are a rationale behind group-targeted vaccines; iv) an outlook for genetic control in infectious diseases, with special emphasis on the concept of molecular networks that will provide a structure to the huge amount of genomic data.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rappuoli, R" uniqKey="Rappuoli R">R Rappuoli</name></author><author><name sortKey="Aderem, A" uniqKey="Aderem A">A Aderem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liolios, K" uniqKey="Liolios K">K Liolios</name></author><author><name sortKey="Chen, Im" uniqKey="Chen I">IM 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Haining</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement><orgName><li>Université d'Aix-Marseille</li></orgName></list><tree><noCountry><name sortKey="Barbosa, T" sort="Barbosa, T" uniqKey="Barbosa T" first="T." last="Barbosa">T. Barbosa</name><name sortKey="Lemaire, D" sort="Lemaire, D" uniqKey="Lemaire D" first="D." last="Lemaire">D. Lemaire</name></noCountry><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Rihet, P" sort="Rihet, P" uniqKey="Rihet P" first="P." last="Rihet">P. Rihet</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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